Abstract: The liver is the most common organ of hematogenous metastasis of colorectal cancer, and about 50% of colorectal cancers will eventually develop liver metastasis, which have become an important untoward factor affecting the survival and prognosis of patients with colorectal cancer. The hepatic artery is the main blood supply vessel for colorectal liver metastases (CRLM), and direct infusion of chemotherapeutic agents through the hepatic artery can improve the local drug concentration and anti-tumor effects. The implantable infusion pumps provide convenient tunnels for infusion chemotherapy easily. The hepatic arterial infusion pump (HAIP) chemotherapy has shown a promising effect in preoperative transformation or downstage of tumors and postoperative adjuvant therapy, which can effectively improve the feasibility of surgical resection of CRLM and reduce the postoperative recurrence rate. The fluorouridine chemotherapy by HAIP can be applied as second or third lines of treatment for patients with CRLM. The HAIP and systemic chemotherapy combination plus targeted therapy can bring better survival benefits for patients in this setting. This article will review and discuss the clinical applications and advances of HAIP chemotherapy in the surgical treatment of CRLM.

Key words: Liver metastases, Colorectal cancer, Hepatic artery infusion pump, Infusion chemotherapy, Fluorouridine