Abstract: Objective The purpose of this study was to analyze the clinical features of patients with pyogenic liver abscess (PLA) with different underlying diseases. Methods The adult PLA patients were encountered in our hospital between January 2007 and December 2020, and the clinical materials were collected and analyzed. Results Out of the 1930 patients with PLA in our series, 926 patients (group A) had no underlying diseases, 592 patients (group B) had type two diabetes mellitus (T2DM), 261 patients (group C) had biliary diseases, and 151 patients (group D) had T2DM and biliary diseases; the percentage of neutrophils in group D was (83.6±9.3)％, much higher than in other three groups (P<0.05), serum albumin levels in group B and group D were 30.3(26.1, 35.1)g/L and 30.8(26.9, 34.1)g/L, much lower than [32.3(28.3, 36.8) g/L, P<0.05] in group A; the incidence of jaundice in group C was 11.9％, significantly higher than 5.5％in group A and 2.7％ in group B(P<0.05), the incidence of pulmonary lesions in group D was 39.1％, significantly higher than 28.3％(P<0.05) in group A, the proportions of aerogenic abscess in group B and group D were 15.4％ and 12.6％, significantly higher than 6.6％(P<0.05) in group A, and the diameter of hepatic abscess in group D was 68.0(50.0, 87.0)mm, significantly higher than in other three groups (P<0.05); the medical costs in group B, group C and group D were 20000.2(10000.5,30000.3) yuan, 20000.3(10000.5, 30000.4) yuan and 20000.4(10000.5, 40000.2) yuan, significantly higher than [10000.9(10000.2, 20000.9) yuan (P<0.05) in group A. Conclusion The PLA patients with underlying diseases might have a severe disease, and have a relatively high hospitalization costs.

Key words: Pyogenic liver abscess, Diabetes, Biliary tract disease, Therapy