Abstract: Objective The aim of this study was to explore the implication of serum adiponectin (APN), 25-hydroxyvitamin D [25-(OH)D] and apolipoprotein B (ApoB) level changes in patients with nonalcoholic fatty liver disease (NAFLD). Methods A total of 117 patients with NAFLD and 51 healthy individuals were enrolled in our hospital between August 2018 and May 2021, and all underwent liver stiffness measurement (LSM) by Fibroscan. Serum 25-(OH)D level was detected by chemiluminescence, and serum APN and ApoB levels were detected by ELISA. Results Based on the controlled attenuated parameters (CAP), the simple fatty liver (SFL) was found in 37 cases, the non-alcoholic steatohepatitis (NASH) was found in 58 cases and the fatty liver-induced cirrhosis was found in 22 cases, and out of them, no liver fibrosis was determined in 81 patients with NAFLD and progressive liver fibrosis in 36 cases; serum APN and 25-(OH)D levels in patients with NAFLD were (9.7±1.9)μg/mL and (30.8±6.4)nmol/L, both significantly lower than [(12.9±2.7)μg/mL and (57.9±8.1)nmol/L, respectively, P<0.05], while serum ApoB level was (1.2±0.2)g/L, significantly higher than [(0.7±0.1)g/L, P<0.05] in healthy persons; serum APN and 25-(OH)D levels in patients with cirrhosis were (7.9±1.3)μg/mL and (24.3±6.9)nmol/L, both significantly lower than [(9.2±2.1)μg/mL and (30.5±7.4)nmol/L, respectively, P<0.05] in patients with NASH or [(11.5±2.5)μg/mL and (35.1±7.1)nmol/L, respectively, P<0.05] in patients with SFL, while serum ApoB level was (1.5±0.2)g/L, significantly higher than [((1.3±0.3)g/L, P<0.05] in patients with NASH or [(0.9±0.1)g/L, P<0.05] in patients with SFL; serum APN and 25-(OH)D levels in patients with progressive liver fibrosis were (8.1±1.4)μg/mL and (25.3±6.7)nmol/L, both significantly lower than [(10.4±2.2)μg/mL and (33.2±7.5)nmol/L, P<0.05], while serum ApoB level was (1.6±0.3)g/L, significantly higher than [(1.0±0.2)g/L, P<0.05] in patients without liver fibrosis. Conclusion Serum APN, 25-(OH)D and ApoB levels are abnormal in patients with NAFLD, which might help predict the disease severity and the progression of liver fibrosis.

Key words: Nonalcoholic fatty liver disease, Adiponectin, Vitamin D, Apolipoprotein B, Implication