Abstract: Objective The aim of this study was to compare the clinical efficacy of laparoscopic hepatectomy (LH) and open hepatectomy (OH) in the treatment of patients with intrahepatic cholangiocarcinoma (ICC). Methods 122 patients with ICC were enrolled in our hospital between February 2018 and February 2021, and were divided into control (n=61) and observation group (n=61), underwent OH or LH. All patients with ICC were followed-up for half a year. Serum C-reactive protein (CRP), cortisol (Cor) and interleukin-6 (IL-6) levels were detected by ELISA. Results The operation time, the intraoperative blood loss, the postoperative first anal exhaust time and the postoperative hospitalization time in patients receiving LH were (232.2±50.4)min, (592.3±164.7)ml, (2.1±0.8)d and (6.5±1.3)d, significantly shorter or less than [(321.1±69.7)min, (995.5±321.4) ml, (2.7±0.7)d and (8.2±1.7)d, respectively, P＜0.0 5] in patients receiving OH; at the end of 3 days after operation, serum CRP, Cor and IL-6 levels in patients receiving LH were (25.1±4.0)mg/L,(529.6±75.4)mmol/L and (83.5±7.2)pg/ml, all significantly lower than [(39.8±5.1)mg/L, (654.7±78.1) mmol/L and (97.3±10.2)pg/ml, respectively, P＜0.05] in patients receiving OH; at 7 days, serum AST level in patients with LH operation was (155.2±12.7)U/L, much lower than [(209.3±17.0)U/L, P＜0.05] in patients with OH operation; at 30 days, the incidence of untoward effects in patient with LH operation was 11.5%, much lower than 26.2%(P＜0.05) in patients with OH operation; at the end of six month follow-up, there were no significant differences respect to the tumor recurrence and the mortality rates between the two groups (3.3% and 3.3% vs. 1.6% and 4.9%, respectively, P＞0.05). Conclusion The LH is a reasonable choice for patients with ICC, with a relative rapid recovery, which might be related to the mild inflammatory reactions.

Key words: Intrahepatic cholangiocarcinoma, Laparoscopic hepatectomy, Open hepatectomy, Therapy