Abstract: Objective The aim of this study was to observe the efficacy of transjugular intrahepatic portosystemie stent (TIPS) and gastric coronary vein embolization (GCVE) in treatment of patients with liver cirrhosis and esophageal varices (EV). Methods 62 patients with decompensated cirrhosis were encountered in our hospital between January 2018 and December 2020, and 33 patients in group A underwent TIPS and GCVE and 29 patients in group B underwent TIPS and endoscopic esophageal varices ligation (EVL). The portal vein blood flow velocity (PVFV), portal venous pressure (PVP) and portal vein pressure gradient (PPG) were detected by ultrasonography. Results At the end of one month after surgery, the PVFV in group A was (15.9±1.8)cm/s, significantly more rapid than [(14.1±1.9)cm/s, P＜0.05] in group B, while the PVP and PPG were (20.3±2.7)mmHg and (9.7±1.2)mmHg, significantly lower than [(22.8±2.9)mmHg and (11.4±0.9)mmHg, respectively, P＜0.05] in group B; at the end of twelve month, the incidence of EV re-bleeding in group A was 6.0%, significantly lower than 31.0%(P＜0.05) in group B, while there were no significant differences as respect to incidences of shunt patency and hepatic encephalopathy (93.9% and 9.1% vs. 93.1% and 6.9%, P>0.05) between the two groups; the fatality in group A was 15.1%, significantly lower than 41.3%(P＜0.05) in group B. Conclusion The efficacy of TIPS and GCVE in dealing with patients with liver cirrhosis and EV is efficacious, which might accelerate the blood flow velocity of portal vein, reduce re-bleeding and improve survivals.

Key words: Liver cirrhosis, Esophageal varices, Transjugular intrahepatic portosystemie stent, Gastric coronary vein embolization, Therapy