Abstract: Objective The aim of this study was to investigate the outcomes of laparoscopic cholecystectomy (LC) and endoscopic retrograde cholangiopancreatography (ERCP) with endoscopic sphincterotomy (EST) in treatment of patients with gallbladder and extrahepatic bile duct stones. Methods A total of 88 patients with gallbladder stones and extrahepatic bile duct stones were admitted to our hospital between January 2018 and October 2020, and were divided into observation group receiving LC and EST combination surgery in 47 cases and control group receiving open cholecystectomy and laparoscopic common bile duct exploration. The visual analogue scales (VAS ) was applied to evaluate the post-operational pain. Results The one-time radical stone removals in the two groups were 93.6% vs. 95.1% (P>0.05); in the observation group, the intraoperative blood loss was (28.1±6.2)ml, significantly less than ,and the operation time, postoperative fasting time and hospital stay were(105.7±25.5)min, (2.2±0.4)d and (7.6±1.0)d, all significantly shorter than in the control; at 48 and 72 hours, the VAS scores in the observation group were (3.7±0.6) and (2.5±0.5), both significantly lower than in the control; 7 days after operation, serum ALT and AST levels in the observation were (46.1±5.6)U/L and (42.5±5.2)U/L, both significantly lower than , while blood lipase level was (808.2±105.7)U/L, significantly higher than in the control; the incidence of post-operational complications in observation group was much lower than that in the control group (4.3% vs. 14.1%, P<0.05). Conclusion The combination of LC and EST under ERCP might have a good outcomes in patients with gallbladder stones and extrahepatic bile duct stones, which could promote postoperative recovery, and less postoperative complications.

Key words: Cholelithiasis, Laparoscopic cholecystectomy, Endoscopic retrograde cholangiopancreatography, Endoscopic sphincterotomy, Therapy