自MR-T2图像勾画肝细胞癌患者放疗靶区精度研究

doi:10.3969/j.issn.1672-5069.2021.04.028

Abstract

Abstract: Objective The aim of this study was to investigate the target delineation accuracy of tumors for radiotherapy based on MR-T2 image in patients with hepatocellular carcinoma (HCC). Methods 36 patients with HCC were enrolled in this study between May 2019 and May 2020, and all patients underwent CT and MRI scan before radiotherapy. The gross tumor volume (GTV), internal gross tumor target volume (IGTV) and planning target volume (PTV) as well as 2%, 50%, 95% and 98% exposure dose of PTV(D2, D50, D95 and D98) were recorded. Results The x, y and z axial displacements of portal vein after Reg refine registration were(0.5±0.2)mm, (0.8±0.3)mm and (0.7±0.3)mm, significantly smaller than [(2.9±0.4)mm,(4.8±0.5)mm and (3.9±0.6)mm, respectively, P<0.05] by automatic deformation registration, and the x, y and z axial displacements of celiac trunk were (0.8±0.4)mm, (0.7±0.3)mm and (0.6±0.3)mm, significantly smaller than [(3.2±0.5)mm, (3.0±0.7)mm and (2.4±0.4)mm, respectively, P<0.05] by automatic deformation registration; the GTV and IGTV after deformation registration were (379.8±103.9)cm³ and (430.1±120.6)cm³, significantly larger than [(330.4±92.8)cm³ and (375.2±95.5)cm³, P<0.05] before deformation registration, while the PTV was (542.7±130.2)cm³, significantly smaller than [(690.2±150.3)cm³, P<0.05] before deformation registration; the exposure doses of D2, D50, D95 and D98 target tumors after deformation registration were (56.0±12.9)Gy, (53.0±6.8)Gy, (49.8±5.3)Gy and (52.9±8.1)Gy, not significantly different compared to [(55.7±13.2)Gy, (52.8±7.3)Gy, (50.1±4.6)Gy and (53.3±7.7)Gy] before deformation registration(P>0.05); the V5, V10, V20, V30 and V40 exposure doses of liver after deformation registration were (52.7±9.4)%, (32.0±5.6)%, (20.1±4.6)%, (13.5±5.2)% and (7.4±3.8)%, significantly lower than [(58.2±10.1)%, (39.3±7.5)%, (24.8±5.8)%, (17.2±4.4)% and (10.1±3.9)%, P<0.05] before deformation registration. Conclusion The target delineation based on MR-T2 imaging for radiotherapy in patients with HCC could help expand the target area and trajectory, and improve the accuracy of target delineation, which might improve the radiotherapy efficacy.

Key words: Hepatoma, MR-T2 images, Radiotherapy, Target delineation accuracy

Gao Jinlong, Wang Haifeng, Li Na, et al. Target delineation accuracy of tumors for radiotherapy based on MR-T2 image in patients with hepatocellular carcinoma[J]. Journal of Practical Hepatology, 2021, 24(4): 565-568.

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Target delineation accuracy of tumors for radiotherapy based on MR-T2 image in patients with hepatocellular carcinoma

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