Abstract: Objective The purpose of this study was to explore the short-term and long-term survivals of patients with huge primary liver cancer (PLC) after associated liver partition and portal vein ligation for staged hepatectomy (ALPPS) . Methods The clinical data of 98 patients with PLC including in our hospital between January 2016 and February 2018 were retrospectively analyzed, and 20 patients were treated with ALPPS (group A), 38 patients underwent surgical resection after transcatheter hepatic arterial chemoembolization (TACE) (group B), and 40 patients received direct resection of huge liver cancer (group C). The liver regeneration was estimated by post-operational CT scan, and the total liver volume (TLV),the remnant liver volume ( RLV) and future remnant liver volume at three months ( FRLV) were calculated, and the regenerative volume (RV) and the regeneration rate (RR) were obtained.Results At 3 months after surgery, the FRLV in group A was (366.3±31.7)mL, significantly greater than (185.2±16.4)mL in group B or (181.9±14.2)mL in group C (P＜0.05), and the RR was (68.8±6.4)%, significantly higher than (21.4±2.0)% in group B or (22.6±2.3)% in group C (P＜0.05); fifteen days after operation, serum albumin level in group A was (37.0±2.7)g/L, significantly higher than (34.1±2.9)g/L in group B or (34.0±3.2)g/L in group C (P＜0.05); the two-year total survival and the progress-free survival in group A were 70.0% and 55.0%, and they were 55.3% and 36.8% in group B and 52.5% and 42.5% in group C, not significantly different among them (P＞0.05).Conclusion The surgery of ALPPS could rapidly increase the remnant liver volume in a short time after operation, and accelerate the postoperative liver function recovery in patients with PLC, which warrants further investigation.

Key words: Hepatoma, Associated liver partition and portal vein ligation for staged hepatectomy, Transcatheter hepatic arterial chemoembolization, Short-term and long-term survival