Abstract: Objective To investigate the hepatic expression of KCNJ15 in mice with MHV-3-induced fulminant hepatitis. Method MHV-3-induced fulminant hepatitis model was established and the hepatic expression of KCNJ15 were assayed by quantitative PCR and immunohistochemistry. KCNJ15 expressions on subgroups of intrahepatic lymphocytes were determined by flow cytometry. Results The enhanced expression of KCNJ15 in liver tissue was observed,especially at 72h after MHV-3 injection. Moreover,the percentage of KCNJ15-producing CD4⁺T cells in the liver at 48h post infection increased to 25.17±7.68%,which was remarkably higher than that of at 0h（3.92±1.33%,P<0.001）;Similarly,hepatic KCNJ15-producing CD8⁺T cells was also increased to 37.08±8.73% with a significant difference as comparing to that of at 0h（6.98±3.48%,P<0.001）;Meanwhile,hepatic NK cells expressed KCNJ15 increased significantly from 7.72±1.34% at 0h to 19.80±4.25% at 24h post infection（P<0.001）. Conclusion The increased expression of KCNJ15 in liver may correlate with immune regulatory function of hepatic lymphocytes,which contributes to virus induced liver failure.