Abstract: Objective To investigate the effect of food intake on the accrracy of fatty liver by the assessment of controlled attenuation parameter（CAP） in patients with liver steatosis. Methods Hepatic CAP values were measured by Fibroscan in 10 volunteers including 7 healthy subjects and 3 with fatty liver with average age of 29 （21~39） yr and body mass index of （22.7±3.13） kg/m²,and the CAPs were obtained at fasting （CAP0）,30 minutes （CAP30）,120 minutes （CAP120） after a standard meal,and the next day of fasting （CAP02）. Results The CAP0,CAP30,CAP120 and CAP02 were（227.8±59.5） dB/m,（244.9±42.1） dB/m,（241.1±51.4） dB/m and （245.7±49.4） dB/m,respectively,with no statistical differences between them（H=0.62,P=0.89）;there was no statistical differences between CAP at fasting state（baseline and the next day fasting）,and at the post-prandial state（30,120 minutes,Z=-1.37,P=0.17）,while the misdiagnosis rates were 5% and 15%,respectively（x²=0.28,P=0.59）. Conclusion The effect of eating on Fibroscan detection of CAP value is not significant,but might increase the rate of misdiagnosis of fatty liver to some extent.