含吡咯烷生物碱的中草药致肝窦阻塞综合征研究进展

doi:10.3969/j.issn.1672-5069.2014.04.033

实用肝脏病杂志 ›› 2014, Vol. 17 ›› Issue (4): 445-455.doi: 10.3969/j.issn.1672-5069.2014.04.033

• 综述 • 上一篇

含吡咯烷生物碱的中草药致肝窦阻塞综合征研究进展

张骏飞综述, 刘波, 陈从新审校

230031 合肥市安徽医科大学解放军临床学院第105医院感染病科

收稿日期:2014-04-15 出版日期:2014-08-30 发布日期:2016-04-11
通讯作者: 陈从新,E-mail:congxinc@aliyun.com
作者简介:张骏飞,男,33岁,博士研究生,主治医师。主要从事肝病诊断与治疗学研究。E-mail: zhangjunfei105@aliyun.com

Increased challenge in traditional Chinese medicine containing pyrrolizidine alkaloids-induced hepatic sinusoidal obstruction syndrome

Zhang Junfei, Liu Bo, Chen Congxin

Department of Infectious Diseases,105 Hospital of PLA,Hefei 230031,Anhui Province,China

Received:2014-04-15 Online:2014-08-30 Published:2016-04-11

摘要/Abstract

摘要： 在临床上,肝窦阻塞综合征比较少见,近年来发病率逐年升高。其主要临床表现为顽固性腹水、黄疸、肝肿大。主要病因是摄入含吡咯烷生物碱的中草药或植物。目前早期诊断困难,无特效治疗方法,主要为对症和支持治疗。本文主要介绍摄入含吡咯烷生物碱的中草药导致的肝窦阻塞综合征的发病机制、病理学和临床表现,以及诊断和治疗方面的进展。

关键词: 肝窦阻塞综合征, 中草药, 吡咯烷生物碱

Abstract: Hepatic sinusoidal obstruction syndrome is rare clinically,but the incidence is recently increased. The clinical manifestations are mainly refractory ascites,jaundice and hepatomegaly.The main causes is the ingestion of pyrrolizidine alkaloids-containing herbs or plants. The early diagnosis is currently difficult. There is no specific therapy for patients with hepatic sinusoidal obstruction syndrome,except for symptomatic and supportive therapy. This review mainly discuss the mechanism,pathology,early diagnosis,and therapy of this entity.

Key words: Hepatic sinusoidal obstruction syndrome, Traditional Chinese medicine, Pyrrolizidine alkaloids

张骏飞综述, 刘波, 陈从新审校. 含吡咯烷生物碱的中草药致肝窦阻塞综合征研究进展[J]. 实用肝脏病杂志, 2014, 17(4): 445-455.

Zhang Junfei, Liu Bo, Chen Congxin. Increased challenge in traditional Chinese medicine containing pyrrolizidine alkaloids-induced hepatic sinusoidal obstruction syndrome[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2014, 17(4): 445-455.

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含吡咯烷生物碱的中草药致肝窦阻塞综合征研究进展

Increased challenge in traditional Chinese medicine containing pyrrolizidine alkaloids-induced hepatic sinusoidal obstruction syndrome

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