关键词: 非酒精性脂肪性肝病, 代谢综合征, 受控衰减参数, 筛查

Abstract: Objective To investigate the application of controlled attenuation parameter （CAP） in screening individuals with risk of metabolic syndrome（MetS）. Methods 662 persons with MetS and 1577 healthy individuals were recruited,and screened by Fibroscan for liver stiffness measure（LSM） and CAP. The clinical parameters were obtained routinely. Results The body mass index （BMI） were [（22.0±2.9） kg/m² and（25.5± 1.4） kg/m²],the waist circumference（WC） were [（78.9±6.7） cm and （85.3±7.1） cm],the systolic blood pressure （SBP） were [（128.0±17.0） mmHg and（139.0±16.0） mmHg] and the diastolic blood pressure （DBP） were [（76.0±9.0） mmHg and（87.0±5.0） mmHg] in healthy persons and in patients with MetS （P<0.001）;the fasting plasma glucose （FPG） levels were [（5.3±0.5） mmol/L and （6.3±0.4） mmol/L],serum triglyceride （TG） levels were [（1.3±0.5） mmol/L and （2.1±0.6） mmol/L],serum total cholesterol （TC） were [（4.7±0.5） mmol/L and （5.0±0.6） mmol/L],HDL-C were [（1.6±0.1） mmol/L and （1.3±0.2） mmol/L],LDL-C were [（2.1±0.3） mmol/L and （2.7±0.5） mmol/L],alanine aminotransferase（ALT） were[（36.5±3.1） U/L and（102.3±4.7） U/L],aspartate aminotransferase （AST） were [（33.4±5.8） U/L and （125.3±7.6） U/L],LSM were[（4.8±0.2） kPa and（6.6±0.3） kPa] and CAP were [（213.1±24.3） dB/m and（269.4±30.2） dB/m] in the two groups （P<0.001）;Logistic analysis showed that BMI,WC,blood pressure,FPG,serum lipid and CAP were the independent risk factors for the development of MetS. Conclusions The screening of individuals with MetS by CAP measure is practical and noninvasive,which warrants further investigation.

Key words: Non-alcoholic fatty liver diseases, Metabolic syndrome, Controlled attenuation parameter, Screening