实用肝脏病杂志 ›› 2018, Vol. 21 ›› Issue (5): 817-820.doi: 10.3969/j.issn.1672-5069.2018.05.045

• 综述 • 上一篇    下一篇

慢性丙型肝炎患者血清自身抗体检测及其临床意义研究现状*

姜宏达 综述, 周海舟 审校   

  1. 150081 哈尔滨市 哈尔滨医科大学(姜宏达); 附属第一医院检验科(周海舟)
  • 收稿日期:2018-01-22 出版日期:2018-09-10 发布日期:2018-09-27
  • 通讯作者: 周海舟,E-mail:happygirl1288@163.com
  • 作者简介:姜宏达,男,26岁,硕士研究生。主要从事肝病免疫防治研究。E-mail: sss741a@163.com
  • 基金资助:
    黑龙江省科学技术研究发展计划项目(编号:2016D02-11)

Serum autoantibodies in patients with hepatitis C

Jiang Hongda, Zhou Haizhou.   

  1. Harbin Medical University,Harbin 150081, Heilongjiang Province,China
  • Received:2018-01-22 Online:2018-09-10 Published:2018-09-27

摘要: 经常发现慢性丙型肝炎病毒(HCV)携带者血清非器官特异性自身抗体(non-organ-specific autoantibodies,NOSA)和抗甲状腺自身抗体(anti-thyroid autoantibodies ATAB)阳性,伴有以自身免疫耐受性丧失为特征的一组自身免疫性疾病,本文将重点介绍这方面的研究进展。

关键词: 丙型肝炎, 自身免疫, 抗体抗核, 自身免疫性甲状腺疾病, 干扰素-α

Abstract: Serum non-organ-specific autoantibodies(NOSA) and anti-thyroid autoantibodies(ATAB) were often found positive in patients with chronic hepatitis C and hepatitis C viral carriers. The patients were characterized by loss of autoimmune tolerance, which might cause a set of autoimmune diseases in this setting. The progress in this field will be discussed in this article.

Key words: Hepatitis C, Autoimmunity, Antinuclear antibodie, Autoimmune thyroid diseases, Interferon-alpha